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CBD - a cure-all?

Cannabidiol (CBD) is a natural substance that has a broad-spectrum of potential therapeutic uses. With rising interest in recent years, scientists across the globe are conducting more and more research to explore these possibilities. While the evidence so far shows that CBD is effective for treating a number of disorders, beware of unproven therapeutic presumptions.

The exact way CBD interacts with the body is still under investigation, but its role is becoming clearer. As with every drug, the dosage determines the effect. The dosages used to treat some disorders are relatively high. No beneficial effect can be expected from a few drops of various CBD-containing extracts. A dosing regimen that is popular, but not scientific.

In the following chapters you’ll find up-to-date information on CBD and its role in prevention and management of different disorders alongside dosing regimens based on hard science.

Benefits of daily use

1. CBD elevates the levels of the endocannabinoid anandamide (the “bliss” molecule), which helps with learning and memory[1].

2. CBD creates a calming effect that can lower stress and improve quality of sleep for individuals struggling with insomnia[2].

3. CBD has neuroprotective and antioxidant properties superior to those of vitamin C and vitamin E[3].

4. CBD oils and creams are effective in the management of skin conditions such as acne and eczemas[4].

5. CBD's anti-inflammatory properties[5] could possibly lower the risk of cancer, metabolic disorders, and neurodegenerativediseases.

6. CBD helps alleviate the psychoactive effects of cannabis smoking, neutralizing the effect of the well-known psychotropic compound THC[6].

7. CBD can help people quit smoking[7],[8].

8. Can be used as a painkiller, if not replacing, at least reducing to some extent the use of opioids[9] - strong pain-relieving medications but highly addictive, that have led to the so-called opioid overdose crisis.

9. Cannabidiol and cannabis extracts with high percentages of cannabidiol can be used on a daily basis, without serious adverse effects. As Lumír Ondřej Hanuš has stated (one of the most important cannabis-researchers of our day) cannabis is "one of the safest known medications”[10].

Dosing reccomendations

Is CBD safe?

Yes, CBD is considered safe for general use.

What is the recommended daily dose?

From 0.5 to 3 mg per kg body weight. Anything under 1 mg per kg

should be considered microdosing.

Should I take it before or after a meal?

CBD should be taken during, or after a meal.

How many times a day should I take CBD?

Take your dose twice a day. Half of it in the morning and the other half in the evening.

Are there any known drug interactions?

Some. Read Side effects for more information.

Bibliography

1. Bloomfield MAP, Green SF, Hindocha C, et al: The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labelling magnetic resonance imaging study. Journal of Psychopharmacology 34: 981-989, 2020.

2. Shannon S, Lewis N, Lee H and Hughes S: Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J 23: 18-041, 2019.

3. Atalay S, Jarocka-Karpowicz I and Skrzydlewska E: Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel) 9: 21, 2019.

4. Palmieri B, Laurino C and Vadalà M: A therapeutic effect of cbd-en- riched ointment in inflammatory skin diseases and cutaneous scars. La Clinica terapeutica 170: e93-e99, 2019.

5. Nagarkatti P, Pandey R, Rieder SA, Hegde VL and Nagarkatti M: Cannabinoids as novel anti-inflammatory drugs. Future Med Chem 1: 1333-1349, 2009.

6. Hudson R, Renard J, Norris C, Rushlow WJ and Laviolette SR: Canna- bidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocan- nabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience 39: 8762-8777, 2019.

7. Hindocha C, Freeman TP, Grabski M, et al: Cannabidiol reverses atten- tional bias to cigarette cues in a human experimental model of tobacco withdrawal. Addiction (Abingdon, England) 113: 1696-1705, 2018.

8. Morgan CJ, Das RK, Joye A, Curran HV and Kamboj SK: Cannabidiol reduces cigarette consumption in tobacco smokers: preliminary findings. Addictive behaviors 38: 2433-2436, 2013.

9. Wiese B and Wilson-Poe AR: Emerging Evidence for Cannabis' Role in Opioid Use Disorder. Cannabis Cannabinoid Res 3: 179-189, 2018.

10. https://www.idnes.cz/zpravy/archiv/konopi-je-jednim-z-nejbezpec-nejsich-znamych-leciv-rika-v-izraeli-pusobici-profesor-lumir-hanus. A100505_091910_kavarna_chu