Bacteria can be found everywhere. They are essential components of our life, maintaining the environment in which we live. Even in a healthy human body, the number of bacteria seems to be almost equal to the body's cells . Nevertheless, a small percentage of the world's bacteria can cause infection and disease. The discovery of penicillin by Alexander Fleming in 1928 laid the foundation for antimicrobial discoveries. New drugs in antibiotic groups such as beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others are used to treat bacterial infections and save countless lives worldwide. Unfortunately, the uncontrolled use of antibiotics, spurred by high numbers of prescriptions, interruption of antibiotic therapy, and use in livestock farming, has created microbes that can resist antibiotics. To meet this challenge, we need both stricter regulation of those already in use and new antibiotics as well.