Bacterial infections and CBD
Bacterial infections and CBD
Bacterial infections

Bacteria can be found everywhere. They are essential components of our life, maintaining the environment in which we live. Even in a healthy human body, the number of bacteria seems to be almost equal to the body's cells [1]. Nevertheless, a small percentage of the world's bacteria can cause infection and disease. The discovery of penicillin by Alexander Fleming in 1928 laid the foundation for antimicrobial discoveries. New drugs in antibiotic groups such as beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others are used to treat bacterial infections and save countless lives worldwide. Unfortunately, the uncontrolled use of antibiotics, spurred by high numbers of prescriptions, interruption of antibiotic therapy, and use in livestock farming, has created microbes that can resist antibiotics. To meet this challenge, we need both stricter regulation of those already in use and new antibiotics as well.

CBD and Bacterial infections

CBD has a broad-spectrum antibacterial action, which could be helpful in the treatment of infections. There is also promising news from a recent study demonstrating that repeated exposure to CBD does not lead to resistance[2]. CBD has shown to be effective against the high-priority gram-negative drug-resistant pathogen N. gonorrhoeae, which is responsible for infections that do not respond to existing antibiotic therapies and against the high-priority gram-positive pathogens vancomycin-resistant E. faecium, and MRSA. Additionally, CBD can be used as an adjuvant therapy together with bacitracin against gram-positive bacteria (Staphylococcus species, Listeria monocytogenes, and Enterococcus faecalis) by inhibiting bacterial growth membrane vesicles, contributing to an overall strong antimicrobial effect [3],[4].

Dosing recommendations for patients with bacterial infections 

Is CBD safe? 

Yes. CBD is considered safe for treatment of bacterial infections. 

What is the recommended daily dose? 

Treatment: 8 mg/kg/day. Start at 1 mg/kg/day and increase 0.5 mg/ kg/day if tolerated well. Read General recommendations! 

Should I take it before or after a meal? 

CBD should be taken during, or after a meal. 

How many times a day should I take CBD? 

Take your dose twice a day. Half of it in the morning and the other half in the evening. 

Are there any known drug interactions? 

Some. Read Side effects for more information.

Bibliography

1. Sender R, Fuchs S and Milo R: Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans. Cell 164: 337-340, 2016. 

2. Blaskovich MAT, Kavanagh AM, Elliott AG, et al: The antimicrobial potential of cannabidiol. Communications Biology 4: 7, 2021. 

3. Kosgodage US, Matewele P, Awamaria B, et al: Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles. Front Cell Infect Microbiol 9: 2019. 

4. Wassmann CS, Højrup P and Klitgaard JK: Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria. Scientific Reports 10: 4112, 2020.