Alzheimer’s disease and CBD
Alzheimer’s disease and CBD
Alzheimer’s disease

Alzheimer’s disease is the most common neurodegenerative disorder and, unfortunately, is poised to become more common as the global population ages. There are currently 30 million people [1] with Alzheimer’s, but researchers project that it could reach 115 by 2050 [2]. The disease is characterized by, among other things [3][4][5], neuronal loss, particularly in the neocortex and hippocampus regions of the brain, eventually leading to memory loss and a decline in cognitive function [1]. Alzheimer’s has two categories, sporadic (95% of the cases) and familial (5% of the cases) [6]. These types seem to be associated with different genes, but there is no distinction between the two regarding symptoms. The only difference is that patients with the familial type tend to develop it earlier. Overall, the cause and mechanisms of Alzheimer’s are still far from fully understood, despite existing hypotheses [7]-[11]. The approved therapies for Alzheimer’s do not stop or reverse the progression of the disease and are only used for the management of symptoms. These include cholinesterase inhibitors, memantine, and NMDA receptor antagonists. However, these treatments only have limited effects [12]. The thinking is that a drug that acts on a single pathway or targets a specific molecule will not influence the complex way the disease unfolds. A multifaceted treatment approach might address a number of issues linked to Alzheimer’s [13][14]. 

CBD and Alzheimer’s disease

The endocannabinoid system is involved in the progression of Alzheimer’s due to its role in oxidative stress, glial cell activation, and clearance of macromolecules [15][16][17]. As CBD modulates the ECS, researchers have tested it in a variety of in vitro [18]-[24] and in vivo [25]-[28] preclinical models, with promising results. Because of these results, research is now shifting to clinical studies [29].

Dosing recommendations for Alzheimer’s patients

Is CBD safe? 

Yes. CBD is considered safe for Alzheimer’s.

What is the recommended daily dose? 

Start with 1 mg/kg/day and titrate to effect - possibly as high as

20 mg/kg/day. Read General recommendations!

Should I take it before or after a meal? 

CBD should be taken during, or after a meal. 

How many times a day should I take CBD? 

Take your dose twice
a day. Half of it in the morning and the other half in the evening. 

Are there any known drug interactions? 

Some. Read Side effects for more information.

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