Cancer and CBD
Cancer and CBD
Cancer

Cancer can refer to more than 100 illnesses with common hallmarks, such as uncontrolled cell growth and invasiveness [1]. It is second only to cardiovascular disease as the cause of death globally and often is the top cause of death in high-income countries [2]. For decades, the standard pharmacological treatment for cancer has been intravenous cytotoxic chemotherapy, which targets rapidly dividing cells. This treatment doesn’t just affect cancer cells, though, and is toxic to healthy cells [3]. There has been enormous progress in cancer treatments in recent years. Researchers have shifted their focus from traditional chemotherapy to novel targeted therapies and immunotherapies (including monoclonal antibodies, cancer vaccines, adoptive cancer therapies, and immune checkpoint therapies) [3],[4],[5]. 

CBD and Cancer

There is strong preclinical experimental evidence (in vitro and in vivo) that CBD possesses anti-cancer properties [6]. Researchers attribute this result to the ability of CBD to modulate signal transduction pathways that are involved in the proliferation and survival of cancer cells [7]. CBD also can activate the immune system to target cancer cells [8] more effectively. 

Our scientific team has substantial data demonstrating the cytotoxic properties of different CBD extracts (produced by PBG Global®) against various cancerous cell lines. We hope that future clinical trials involving cannabidiol across multiple cancer types will verify these promising preclinical results at the clinical level. 

 

Dosing recommendations 
for Cancer patients

Is CBD safe? 

Yes. CBD is considered safe for cancer.

What is the recommended daily dose? 

Titrate to effect: up to 4 mg/kg/day as antiemetic and up to 10 mg/ kg/day as pain relief. For anti-cancer doses - consult your doctor. Read General recommendations!

Should I take it before or after a meal? 

CBD should be taken during, or after a meal. 

How many times a day should I take CBD? 

Take your dose twice a day. Half of it in the morning and the other half in the evening. 

Are there any known drug interactions?

Some. Read Side effects for more information. 

Bibliography

1. (MD) B: Understanding Cancer. National Institutes of Health (US) 2007. 

2. Dagenais GR, Leong DP, Rangarajan S, et al: Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study. The Lancet 395: 785-794, 2020. 

3. Kumar M, Nagpal R, Hemalatha R, et al: Targeted cancer therapies: the future of cancer treatment. Acta bio-medica : Atenei Parmensis 83: 220-233, 2012. 

4. Baudino TA: Targeted Cancer Therapy: The Next Generation of Cancer Treatment. Current drug discovery technologies 12: 3-20, 2015. 

5. Zhang H and Chen J: Current status and future directions of cancer immunotherapy. Journal of Cancer 9: 1773-1781, 2018. 

6. Śledziński P, Zeyland J, Słomski R and Nowak A: The current state and future perspectives of cannabinoids in cancer biology. Cancer medicine 7: 765-775, 2018. 

7. Kis B, Ifrim FC, Buda V, et al: Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer. International journal of molecular sciences 20: 2019. 

8. Haustein M, Ramer R, Linnebacher M, Manda K and Hinz B: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochemical Pharmacology 92: 312-325, 2014.