Other therapeutic applications
Other therapeutic applications

CBD and hemp extracts high in CBD may have uses beyond those listed in this book. Preclinical evidence suggests that it can play a positive role in the prevention of cardiovascular disease [1] and diabetes [2][3], but much more research is needed to draw any conclusions. 

In addition, the ECS seems to play a role in bone metabolism [4][5], leading to the question of whether cannabinoids, in general, may have application for osteoporosis as antiresorptive and/or bone anabolic agents [6]. 

CBD could also help alleviate menstrual discomfort. Over 20 000 women currently use Daye®’s CBD tampons, harnessing the power of cannabinoids locally. Clinical trials conducted during the development of the tampons show that PBG Global®’s CBD full-spectrum extract is safe and effective for this female health application. 

If you’re wondering whether CBD could help your specific health condition, there are safe ways to experiment. However, proceed only after consulting with your doctor. Also, make sure to follow the instructions on "titration to effect" in General recommendations and pay attention to the warnings in Side effects

The endocannabinoid system (ECS) and CBD, in particular, have drawn the attention of researchers around the world. New medicinal evidence is expected to emerge in the coming years. We will keep you updated with forthcoming issues of the Little Red Book of CBD.


1. Stanley CP, Hind WH and O'Sullivan SE: Is the cardiovascular system a therapeutic target for cannabidiol? British journal of clinical pharmacology 75: 313-322, 2013. 

2. Lehmann C, Fisher NB, Tugwell B, Szczesniak A, Kelly M and Zhou J: Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes. Clinical hemorheology and microcirculation 64: 655-662, 2016. 

3. Weiss L, Zeira M, Reich S, et al: Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity 39: 143-151, 2006. 

4. Bab I, Ofek O, Tam J, Rehnelt J and Zimmer A: Endocannabinoids and the regulation of bone metabolism. Journal of neuroendocrinology 20 Suppl 1: 69-74, 2008. 

5. Tam J, Trembovler V, Di Marzo V, et al: The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22: 285-294, 2008. 

6. Idris AI: Cannabinoid receptors as target for treatment of osteoporosis: a tale of two therapies. Curr Neuropharmacol 8: 243-253, 2010.